The Challenge for Antibacterial Drugs Against Multidrug-Resistant Bacteria: Antibacterial Drugs without Causing Resistance
نویسندگان
چکیده
منابع مشابه
The resistance of bacteria to antibacterial drugs: a selective review.
Bacteria may be resistant to antibacterial drugs because of some alterable property of the cell or the environment ('phenotypic resistance') or some alteration of the usual genetic properties of the cell ('genotypic resistance'). Genotypic resistance can be mediated by a mutation of the bacterial chromosome or the infection of the cell by an extrachromosomal element, e.g. an R factor. The prope...
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Successful small-molecule antibacterial agents must meet a variety of criteria. Foremost is the need for selectivity and safety: It is easy to kill bacteria with chemicals, but difficult to do it without harming the patient. Other requirements are possession of a useful antibacterial spectrum, no cross-resistance with existing therapeutics, low propensity for rapid resistance selection, and pha...
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OBJECTIVES To screen methanolic leaf extracts of 21 timber-yielding plants for antibacterial activity against nine species of uropathogenic bacteria isolated from clinical samples of a hospital (Enterococcus faecalis, Staphylococcus aureus, Acinetobacter baumannii, Citrobacter freundii, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginos...
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BACKGROUND Many edible plants are used in Cameroon since ancient time to control microbial infections. This study was designed at evaluating the antibacterial activities of the methanol extracts of ten Cameroonian vegetables against a panel of twenty nine Gram negative bacteria including multi-drug resistant (MDR) strains. METHODS The broth microdilution method was used to determine the Minim...
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The increased incidence of Multidrug-Resistant Mycobacterium tuberculosis (MDR-MT) requires the search for alternative antimycobacterial drugs. The main aim of this study was to evaluate the dichloromethane extract from Aristolochia brevipes (Rhizoma) and the compounds isolated from this extract against several mycobacterial strains, sensitive, resistant (monoresistant), and clinical isolates (...
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ژورنال
عنوان ژورنال: KAGAKU TO SEIBUTSU
سال: 2019
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu.57.416